Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Tracking end-of-life stage of chemicals: A scalable data-centric and chemical-centric approach. [PDF]
Resour Conserv Recycl, 2023 Hernandez-Betancur JD +2 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A data-centric approach to detecting and mitigating demographic bias in pediatric mental health text. [PDF]
Commun Med (Lond)Ive J +11 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Data-Centric AI for EEG-Based Emotion Recognition: Noise Filtering and Augmentation Strategies. [PDF]
Bioengineering (Basel)Moghadam N, Hegazy R.
europepmc +1 more source
Aligning Object-Centric Event Logs with Data-Centric Conceptual Models
, 2023 Goossens, Alexandre +4 more
openaire +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Rethinking deep learning in bioimaging through a data centric lens. [PDF]
Npj ImagingCao J +13 more
europepmc +1 more source
A data-centric way to improve entity linking in knowledge-based question answering. [PDF]
PeerJ Comput Sci, 2023 Liu S, Zhou G, Xia Y, Wu H, Li Z.
europepmc +1 more source