Results 151 to 160 of about 511,690 (285)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Data Centric HitL Framework for Conducting aSsystematic Error Analysis of NLP Datasets using Explainable AI. [PDF]

Sci Rep
El-Sayed A, Nasr A, Mohamed Y, Alaaeldin A, Ali M, Salah O, Khalid A, Lazem S.   +7 more
europepmc   +1 more source

Understanding the illicit drug distribution in England: a data-centric approach to the County Lines Model. [PDF]

R Soc Open Sci, 2023
Castro-Gonzalez L.
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Data-centric artificial intelligence and cancer research: construction of a real-world head and neck treatment data repository. [PDF]

ESMO Real World Data Digit Oncol
Butterworth V, Young T, Drake H, Palmer I, Avgoulea T, Ivy E, Andriolo J, Creppy C, Routledge C, Adjogatse D, Kong A, Petkar I, Reis Ferreira M, Eaton D, Lei M, Misson S, Vilic D, Guerrero Urbano T.   +17 more
europepmc   +2 more sources

Model-Centric or Data-Centric Approach? A Case Study on the Classification of Surface Defects in Steel Hot Rolling Using Convolutional Neural Networks. [PDF]

Sensors (Basel)
López de la Rosa F, Gómez-Sirvent JL, Sánchez-Reolid R, Morales R, Fernández-Caballero A.   +4 more
europepmc   +1 more source

Rapidly predicting Kohn-Sham total energy using data-centric AI. [PDF]

Sci Rep, 2022
Kurban H, Kurban M, Dalkilic MM.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Federated learning: a privacy-preserving approach to data-centric regulatory cooperation. [PDF]

Front Drug Saf Regul
Horst A, Loustalot P, Yoganathan S, Li T, Xu J, Tong W, Schneider D, Löffler-Perez N, Di Renzo E, Renaudin M.   +9 more
europepmc   +1 more source

Models and methods: a perspective of the impact of six IMI translational data-centric initiatives for Alzheimer's disease and other neuropsychiatric disorders. [PDF]

Front Neurol, 2023
North H, Hofmann-Apitius M, Kas MJH, Marston H, Haas M.   +4 more
europepmc   +1 more source