Results 131 to 140 of about 803,970 (265)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Deriving proxy life cycle assessment datasets for manufacturing machines through data clustering. [PDF]

Int J Adv Manuf Technol
Dodd N, Koh L, Rothman R.
europepmc   +1 more source

Deep single-cell RNA-seq data clustering with graph prototypical contrastive learning. [PDF]

Bioinformatics, 2023
Lee J, Kim S, Hyun D, Lee N, Kim Y, Park C.   +5 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Compact and informative representation learning for scRNA-seq data clustering with masked information bottleneck. [PDF]

BMC Biol
Yan X, Han F, Wu Y, Tian Z.
europepmc   +1 more source

MOCSS: Multi-omics data clustering and cancer subtyping via shared and specific representation learning. [PDF]

iScience, 2023
Chen Y, Wen Y, Xie C, Chen X, He S, Bo X, Zhang Z.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Adaptive multi-view information bottleneck for multi-omics data clustering. [PDF]

Brief Bioinform
Tian Z, Wei X, Lou Z, Teng Z, Fu S.
europepmc   +1 more source

An interpretable single-cell RNA sequencing data clustering method based on latent Dirichlet allocation. [PDF]

Brief Bioinform, 2023
Yang Q, Xu Z, Zhou W, Wang P, Jiang Q, Juan L.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source