Results 71 to 80 of about 25,970,551 (304)

Accelerating Bayesian hierarchical clustering of time series data with a randomised algorithm [PDF]

, 2013
We live in an era of abundant data. This has necessitated the development of new and innovative statistical algorithms to get the most from experimental data.
Cooke, Emma J., Wild, David L., Robert Darkins, Emma J Cooke, Darkins Robert, Cooke Emma J., Ghahramani Zoubin, Savage, Richard S., Paul D W Kirk, David L Wild, Ghahramani, Zoubin, Kirk Paul D. W., Zoubin Ghahramani, Richard S Savage, Darkins, Robert, Savage Richard S., Kirk, P. (Paul), Wild David L.   +17 more
core   +1 more source

A Hybrid Data Clustering Algorithm Using Modified Krill Herd Algorithm and K-MEANS [PDF]

Journal of Advances in Computer Engineering and Technology, 2019
Data clustering is the process of partitioning a set of data objects into meaning clusters or groups. Due to the vast usage of clustering algorithms in many fields, a lot of research is still going on to find the best and efficient clustering algorithm ...
Jensi R
doaj  

Data Clustering Using Moth-Flame Optimization Algorithm

Sensors, 2021
A k-means algorithm is a method for clustering that has already gained a wide range of acceptability. However, its performance extremely depends on the opening cluster centers.
Tribhuvan Singh, Nitin Saxena, Manju Khurana, Dilbag Singh, Mohamed Abdalla, Hammam Alshazly   +5 more
doaj   +1 more source

Data ultrametricity and clusterability

Journal of Physics: Conference Series, 2019
Abstract The increasing needs of clustering massive datasets and the high cost of running clustering algorithms poses difficult problems for users. In this context it is important to determine if a data set is clusterable, that is, it may be partitioned efficiently into well-differentiated groups containing similar objects.
Dan A. Simovici, Kaixun Hua
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Big Privacy: Challenges and Opportunities of Privacy Study in the Age of Big Data

IEEE Access, 2016
One of the biggest concerns of big data is privacy. However, the study on big data privacy is still at a very early stage. We believe the forthcoming solutions and theories of big data privacy root from the in place research output of the privacy ...
Shui Yu
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Multi-type relational clustering approaches : current state-of-the-art and new directions [PDF]

, 2008
The proliferation of multi-type relational datasets in a number of important real-world applications and the limitations resulting from the transformation of such datasets to fit propositional data mining approaches have led to the emergence of the ...
Anand, Sarabjot Singh, Li, Tao
core   +1 more source