Results 81 to 90 of about 3,772,561 (311)

Cognitive and kidney function: results from a British birth cohort reaching retirement age.

PLoS ONE, 2014
BackgroundPrevious studies have found associations between cognitive function and chronic kidney disease. We aimed to explore possible explanations for this association in the Medical Research Council National Survey of Health and Development, a ...
Richard J Silverwood, Marcus Richards, Mary Pierce, Rebecca Hardy, Naveed Sattar, Charles Ferro, Caroline Savage, Diana Kuh, Dorothea Nitsch, NSHD scientific and data collection teams   +9 more
doaj   +1 more source

CloudGripper: An Open Source Cloud Robotics Testbed for Robotic Manipulation Research, Benchmarking and Data Collection at Scale [PDF]

, 2023
Muhammad Zahid, Florian T. Pokorny
openalex   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Quantifying the Tolerability of Antipsychotic Treatment-Related Side Effects in Schizophrenia: A Survey Study of Patients and Caregiver Proxies

Patient Preference and Adherence
Melissa Culhane Maravic,1 Kelly Birch,1 Anh Thy H Nguyen,1 Alicia Subasinghe,2 Elizabeth Stafford,3 Christopher Zacker2 1Precision AQ, New York, NY, USA; 2Cerevel Therapeutics, Cambridge, MA, USA; 3National Alliance on Mental Illness, Arlington, VA ...
Maravic MC, Birch K, Nguyen ATH, Subasinghe A, Stafford E, Zacker C   +5 more
doaj  

Calibration and data collection protocols for reliable lattice parameter values in electron pair distribution function studies [PDF]

, 2015
A. M. Milinda Abeykoon, Hefei Hu, Lijun Wu, Yimei Zhu, Simon J L Billinge, A. M. Milinda Abeykoon, Hefei Hu, Lijun Wu, Yimei Zhu, Simon J L Billinge   +9 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Experiences with Higher-Risk Myelodysplastic Syndromes and Improving Patient-Centered Treatment Decision-Making: A Qualitative Study of Patients, Caregivers, and Providers

Cancer Management and Research
Melissa Culhane Maravic,1 Natalie Land,1 Nadya Prood,1 Claire Cagle,1 Suepattra G May,1 Katharine Batt,1,2 Eduardo J Sabate,3 Ngozi Afulezi,3 Teraneh Z Jhaveri,3 Tracey Iraca,4 Cosmina Hogea3 1Precision AQ, Bethesda, MD, USA; 2Sprouts Consulting, Ltd ...
Maravic MC, Land N, Prood N, Cagle C, May SG, Batt K, Sabate EJ, Afulezi N, Jhaveri TZ, Iraca T, Hogea C   +10 more
doaj  

Who Will Author the Synthetic Texts? Evoking Multiple Personas from Large Language Models to Represent Users’ Associative Thesauri

Big Data and Cognitive Computing
Previously, it was suggested that the “persona-driven” approach can contribute to producing sufficiently diverse synthetic training data for Large Language Models (LLMs) that are currently about to run out of real natural language texts. In our paper, we
Maxim Bakaev, Svetlana Gorovaia, Olga Mitrofanova   +2 more
doaj   +1 more source