Results 41 to 50 of about 350,072 (251)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
ACM Computing Surveys, 1987 This paper surveys a variety of data compression methods spanning almost 40 years of research, from the work of Shannon, Fano, and Huffman in the late 1940s to a technique developed in 1986. The aim of data compression is to reduce redundancy in stored or communicated data, thus increasing effective data density.
Lelewer, Debra A., Hirschberg, Daniel S.
openaire +3 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Deep Lossless Compression Algorithm Based on Arithmetic Coding for Power Data
Sensors, 2022 Classical lossless compression algorithm highly relies on artificially designed encoding and quantification strategies for general purposes. With the rapid development of deep learning, data-driven methods based on the neural network can learn features ...
Zhoujun Ma +4 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Golomb–Rice Coder-Based Hybrid Electrocardiogram Compression System
Engineering Proceedings, 2023 Heart-related ailments have become a significant cause of death around the globe in recent years. Due to lifestyle changes, people of almost all age brackets face these issues.
Sachin Himalyan, Vrinda Gupta
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dental Research Journal, 2014 Background: With increase of digital imaging, the need for storage space and transmission speed also increases. Compressed images need less storage space and decrease the transmission time. However, compression could compromise image quality.
Sima Saghaie, Roshanak Ghaffari
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Research on Compression Algorithm of Zone Controller Record DataBased on Huffman Coding
Kongzhi Yu Xinxi Jishu, 2020 Zone controller(ZC) subsystem in the communication based train control(CBTC) system is a full-time continuously working equipment, which is in the center of data interaction of the whole system.
WANG Fuyuan, LEI Chengjian, REN Jianxin
doaj