Results 131 to 140 of about 51,655,942 (350)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Integrating screening and management of mental disorders, including substance use disorders into other non-communicable disease care: insights from theory-informed implementation strategies creation for implementation model M0 in Faridabad, India as part of ICMR-MINDS project

open access: yesFrontiers in Health Services
BackgroundMental disorders, including substance use disorders (MSUD) frequently co-occur with other Non-Communicable Diseases (NCDs). This leads to increased morbidity, premature mortality, and reduced quality of life.
Yatan Pal Singh Balhara   +11 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Identification of Lagged Duration Dependence in Multiple Spells Competing Risks Models [PDF]

open access: yes
We show non-parametric identification of lagged duration dependence in mixed proportional hazard models for duration data, in the presence of competing risks and consecutive spells.
Guillaume HORNY, Matteo PICCHIO
core  

Download statistics GESIS Data Archive

open access: yes, 2019
General information: The data sets contain information on how often materials of studies available through GESIS: Data Archive for the Social Sciences were downloaded and/or ordered through one of the archive´s plattforms/services between 2004 and 2018.
GESIS - Data Archive for the Social Sciences
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

A Monte Carlo Evaluation of Some Common Panel Data Estimators when Serial Correlation and Cross-sectional Dependence are Both Present [PDF]

open access: yes
This study employs Monte Carlo experiments to evaluate the performances of a number of common panel data estimators when serial correlation and cross-sectional dependence are both present.
W. Robert Reed, Haichun Ye
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

An M-estimator of multivariate tail dependence. [PDF]

open access: yes
AN M-ESTIMATOR OF TAIL DEPENDENCE. Extreme value theory is the part of probability and statistics that provides the theoretical background for modeling events that almost never happen.
Krajina, A.
core  

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