Results 111 to 120 of about 3,447,982 (286)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

CanDIG: Federated network across Canada for multi-omic and health data discovery and analysis. [PDF]

Cell Genom, 2021
Dursi LJ, Bozoky Z, de Borja R, Li H, Bujold D, Lipski A, Rashid SF, Sethi A, Memon N, Naidoo D, Coral-Sasso F, Wong M, Quirion PO, Lu Z, Agarwal S, Pavlov Y, Ponomarev A, Husic M, Pace K, Palmer S, Grover SA, Hakgor S, Siu LL, Malkin D, Virtanen C, Pugh TJ, Jacques PÉ, Joly Y, Jones SJM, Bourque G, Brudno M.   +30 more
europepmc   +1 more source

Keywords for data discovery

, 2021
Finding research data is often described as difficult or challenging (Brickley, Burgess, & Noy, 2019) (Chapman, et al., 2020), especially in comparison to literature search (Kern & Mathiak, 2015). From observation (Krämer, Papenmeier, Carevic, Kern, & Mathiak, 2021) and surveys (Gregory, Groth, Scharnhorst, & Wyatt, 2020) (Friedrich ...
openaire   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Conceptions of data literacy in the statistics education literature

IASSIST Quarterly
Data literacy is an increasingly important skill in our data-driven world, and librarians and other information professionals can play a key role in creating a data literate population due to data literacy’s close association with information literacy ...
Julia Bauder, Libby Cave
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Publicly available soil moisture datasets: an overview and the UB-SMDC portal

Big Earth Data
Soil moisture is a fundamental environmental variable essential for applications in agriculture, drought assessment, hydrological modeling, and climate research.
Farzane Mohseni, Jan-Henrik Haunert
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PathQC: Determining Molecular and Structural Integrity of Tissues from Histopathological Slides

Bioengineering
Quantifying tissue, molecular, and structural integrity is essential for biobank development. However, current assessment methods either involve destructive testing that depletes valuable biospecimens or rely on manual evaluations, which are not scalable
Ranjit Kumar Sinha, Anamika Yadav, Sanju Sinha   +2 more
doaj   +1 more source

Privacy-protecting, reliable response data discovery using COVID-19 patient observations. [PDF]

J Am Med Inform Assoc, 2021
Kim J, Neumann L, Paul P, Day ME, Aratow M, Bell DS, Doctor JN, Hinske LC, Jiang X, Kim KK, Matheny ME, Meeker D, Pletcher MJ, Schilling LM, SooHoo S, Xu H, Zheng K, Ohno-Machado L, R2D2 Consortium.   +18 more
europepmc   +1 more source