Results 131 to 140 of about 28,374,038 (313)
, 2021 Finding research data is often described as difficult or challenging (Brickley, Burgess, & Noy, 2019) (Chapman, et al., 2020), especially in comparison to literature search (Kern & Mathiak, 2015). From observation (Krämer, Papenmeier, Carevic, Kern, & Mathiak, 2021) and surveys (Gregory, Groth, Scharnhorst, & Wyatt, 2020) (Friedrich ...
openaire +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A SIMULATION STUDY OF DATA DISCOVERY MECHANISM FOR SCIENTIFIC DATA GRID ENVIRONMENT
Journal of ICT, 2004 Research in the area of grid computing has given us various ideas and solutions to address the requirements in a modern scientific computing community that managed massive amounts of a very large data collections in a geographically distributed ...
A. Abdullah +4 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
BiomedicinesBackground: Despite remarkable progress in clinical management of patients and intensified screening, colorectal cancer remains the second most common cause of cancer-related death in the United States.
Mark Fertel +2 more
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Privacy-protecting, reliable response data discovery using COVID-19 patient observations. [PDF]
J Am Med Inform Assoc, 2021 Kim J +18 more
europepmc +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
DASHBOARD INDICATORS OF THE PUBLIC SERVICE
Вестник университета, 2019 It formulated the need for new guidelines that take into account the possibility of formalization and analysis of processes in the discharge of public functions by public servants.
N. Altuhova +3 more
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