Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Earthquake-Resilient Structural Control Using PSO-Based Fractional Order Controllers
Fractal and FractionalSeismic-induced vibration mitigation in multi-degree-of-freedom (MDOF) building structures calls for efficient and adaptive control strategies. Fractional-order PIλDμ controllers allow increased flexibility in tuning when compared with the conventional ...
Sanoj Kumar +3 more
doaj +1 more source
A Very Low Resource Language Speech Corpus for Computational Language Documentation Experiments
, 2018 Most speech and language technologies are trained with massive amounts of speech and text information. However, most of the world languages do not have such resources or stable orthography.
Adda, G. +13 more
core
Directory of aerospace safety specialized information sources [PDF]
, 1974 Directory aids safety specialists in locating information sources and individual experts in engineering-related fields. Lists 170 organizations and approximately 300 individuals who can provide safety-related technical information in form of ...
Fullerton, E. A. +3 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Optimization-Driven Reconstruction of 3D Space Curves from Two Views Using NURBS
MathematicsIn the realm of 3D curve reconstruction, Non-Uniform Rational B-Splines (NURBSs) offer a versatile mathematical tool due to their ability to precisely represent complex geometries.
Musrrat Ali +3 more
doaj +1 more source
Global data bases on distribution, characteristics and methane emission of natural wetlands: Documentation of archived data tape [PDF]
Global digital data bases on the distribution and environmental characteristics of natural wetlands, compiled by Matthews and Fung (1987), were archived for public use.
Matthews, Elaine
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Sequential Multimodal Biometric Authentication Fusion System
MathematicsThe current study proposes an improved DenseNet-based Sequential Multimodal Biometric Authentication System, involving face and ear modality for better human identification. The architecture is composed of three convolutional layers and two dense layers,
Swati Rastogi +3 more
doaj +1 more source
Documentation of the detailed radiation property data for the radiation-ablation code RASLE [PDF]
This report is a documentation of the necessary radiation property input data for the radiating shock layer simulation code RASLE. The tabulated data are required to simulate systems which are composed of oxygen, nitrogen, carbon, hydrogen, and silicon ...
Henline, William D.
core +1 more source