Results 151 to 160 of about 2,018,475 (309)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Data Management Document [PDF]

, 2020
openaire   +1 more source

Flight test and evaluation of Omega navigation in a general aviation aircraft. Volume 2: Appendices [PDF]

Detailed documentation for each flight of the Omega Flight Evaluation study is presented, including flight test description sheets and actual flight data plots.
Hoffman, W. C., Howell, J. D., Hwoschinsky, P. V., Wischmeyer, C. E.   +3 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Negligence in data recording during institutional birth: exploring health workers' perspectives on the barriers and enablers of data documentation practices. [PDF]

Arch Public Health
Taye BK, Gezie LD, Atnafu A, Mengiste SA, Kaasbøll J, Gullslett MK, Tilahun B.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Radicular Cysts and Periapical Granulomas: Data Documentation for 696 Cases and Findings on Fibrosis, and Porphyromonas gingivalis and Fusobacterium nucleatum in These Lesions. [PDF]

Clin Exp Dent Res
Virkkunen S, Kaarela T, Laine M, Suominen A, Hagström J, Sorsa T, Haglund C.   +6 more
europepmc   +1 more source

Documentation of data of JGOFS project ALMOFRONT [PDF]

, 2012
ALMOFRONT project members
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Lunar laser ranging data deposited in the National Space Science Data Center: Unfiltered photon detections for September 1969 through June 1970 [PDF]

Documentation is presented which is to be used in conjunction with the deposition in the National Space Science Data Center of the unfiltered data obtained during laser ranging operations between the McDonald Observatory and the reflector at Tranquility ...
Mulholland, J. D.
core   +1 more source