Results 111 to 120 of about 26,367,629 (301)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

ITER: An algorithm for predictive regression rule extraction. Data warehousing and knowledge discovery. Proceedings. [PDF]

Various benchmarking studies have shown that artificial neural networks and support vector machines have a superior performance when compared to more traditional machine learning techniques.
Vanthienen, Jan, Baesens, Bart, Huysmans, Johan   +2 more
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Data Extractions Using a Large Language Model (Elicit) and Human Reviewers in Randomized Controlled Trials: A Systematic Comparison

Cochrane Evidence Synthesis and Methods
Aim We aimed at comparing data extractions from randomized controlled trials by using Elicit and human reviewers. Background Elicit is an artificial intelligence tool which may automate specific steps in conducting systematic reviews. However, the tool's
Joleen Bianchi, Julian Hirt, Magdalena Vogt, Janine Vetsch   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Probabilistic visual relational data extraction [PDF]

, 2010
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-12-09T14:11:23Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No.
Bui, Ngoc T.
core  

Extraction and description of 3D (articulated) moving objects

, 2002
We seek to extract the three-dimensional motion of articulated objects by passive sensing. We first develop a multi-view system that segments objects from the background before their subsequent analysis by a motion model.
Karl J Sharman, Sharman, Karl, Nixon, Mark S., Mark S Nixon, John N Carter, Carter, John N.   +5 more
core   +1 more source

Using Artificial Intelligence Tools as Second Reviewers for Data Extraction in Systematic Reviews: A Performance Comparison of Two AI Tools Against Human Reviewers

Cochrane Evidence Synthesis and Methods
Background Systematic reviews are essential but time‐consuming and expensive. Large language models (LLMs) and artificial intelligence (AI) tools could potentially automate data extraction, but no comprehensive workflow has been tested for different ...
T. Helms Andersen, T. M. Marcussen, A. D. Termannsen, T. W. H. Lawaetz, O. Nørgaard   +4 more
doaj   +1 more source