Results 91 to 100 of about 26,367,629 (301)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

PubMed-Scale Event Extraction for Post-Translational Modifications, Epigenetics and Protein Structural Relations [PDF]

, 2012
Recent efforts in biomolecular event extraction have mainly focused on core event types involving genes and proteins, such as gene expression, protein-protein interactions, and protein catabolism.
Björne, Jari, Ginter, F, Van de Peer, Yves, Ohta, T, Ohta, Tomoko, Van Landeghem, S, Van Landeghem, Sofie, Pyysalo, S, Ananiadou, S; id_orcid, Van de Peer, Y, Ananiadou, Sophia, Salakoski, Tapio, Björne, J, Ginter, Filip, Salakoski, T, Pyysalo, Sampo   +15 more
core  

Portable extraction of partially structured facts from the web [PDF]

, 2010
A novel fact extraction task is defined to fill a gap between current information retrieval and information extraction technologies. It is shown that it is possible to extract useful partially structured facts about different kinds of entities in a broad
Inguna Skadiņa, Andrew Salway, Kelly, Liadh, Gareth J. F. Jones, Gareth Jones, Salway, Andrew, Liadh Kelly, Jones, Gareth J.F., Skadiņa, Inguna   +8 more
core   +2 more sources

Unsupervised Relation Extraction for E-Learning Applications [PDF]

, 2011
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn this modern era many educational institutes and business organisations are adopting the e-Learning approach as it ...
Afzal, Naveed
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Automated extraction of structured information from a variety of web pages

, 2018
The expediency of using methods of structured data extraction from a set of HTML pages for the information search in the Internet is substantiated. The main methods of structured data extraction from the set of web pages, which are formed by a common ...
Pogorilyy, S.D., Kramov, A.A.
core  

ReviewAid: An Open-Source Tool for Efficient PICO-Based Screening and Data Extraction in Systematic Reviews

Journal of Open Research Software
Systematic reviews are widely utilized as a rigorous method for synthesizing scientific evidence, yet the manual process of screening literature and extracting data remains a time-consuming bottleneck.
Vihaan Sahu, Mohith Balakrishnan
doaj   +1 more source

Extraction, Processing and Visualization of Peer Assessment Data in Moodle

Applied Sciences, 2019
Situated in the intersection of two emerging trends, online self- and peer assessment modes and learning analytics, this study explores the current landscape of software applications to support peer assessment activities and their necessary requirements ...
Julián Chaparro-Peláez, Santiago Iglesias-Pradas, Francisco J. Rodríguez-Sedano, Emiliano Acquila-Natale   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source