Results 81 to 90 of about 26,367,629 (301)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Web-based System for Digital Presentation, Management and Preservation of Bulgarian Language Heritage

Digital Presentation and Preservation of Cultural and Scientific Heritage, 2015
The paper briefly describes a web-based software system for presentation, processing and management of Bulgarian language resources as a part of the Bulgarian cultural heritage. The system will be available in the cyberspace.
Ralitsa Dutsova
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Scalable Extraction of Big Macromolecular Data in Azure Data Lake Environment

Molecules, 2019
Calculation of structural features of proteins, nucleic acids, and nucleic acid-protein complexes on the basis of their geometries and studying various interactions within these macromolecules, for which high-resolution structures are stored in Protein ...
Dariusz Mrozek, Tomasz Dąbek, Bożena Małysiak-Mrozek   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Update of the Xylella spp. host plant database – Systematic literature search up to 31 December 2024

EFSA Journal
This scientific report provides an update of the Xylella spp. host plant database, aiming to provide information and scientific support to risk assessors, risk managers and researchers dealing with Xylella spp.
European Food Safety Authority (EFSA), Vincenzo Cavalieri, Elisa Fasanelli, Giandomenico Furnari, Davide Gibin, Alicia Gutierrez Linares, Pierfederico La Notte, Luca Pasinato, Giuseppe Stancanelli   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Advanced Computer Vision Techniques for Accurate Measurement in Unmanned Mobile Robots

Measurement Science Review
For years, researchers have been studying computer vision, i.e. the ability of artificial intelligence (AI) systems to perceive and interpret visual data like humans.
Bharathi V, Natraj N A, Gopinath S, Kiruthikaa R   +3 more
doaj   +1 more source

Beat the Offers—A Machine-Learning Approach for Predicting Contestants’ Choices and Games’ Outcomes on a TV Quiz Show

Applied Sciences
Beat the Chasers is a popular UK-originating TV quiz show that premiered in Croatia in 2023. On the show, a contestant challenges a team of up to five chasers with respect to the offers provided by the production.
Hana Ivandic, Branimir Pervan, Josip Knezovic, Alan Jovic   +3 more
doaj   +1 more source