Results 221 to 230 of about 4,028,722 (294)

Development and Validation of a Generative Artificial Intelligence-Based Pipeline for Automated Clinical Data Extraction From Electronic Health Records: Technical Implementation Study. [PDF]

JMIR Bioinform Biotechnol
Carlisle MN, Pace WA, Liu AW, Krumm R, Cowan JE, Carroll PR, Cooperberg MR, Odisho AY.   +7 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Comparing the accuracy of AI-assisted data extraction versus human double extraction in evidence synthesis: a randomised controlled trial protocol. [PDF]

BMJ Open
Peng Z, Fan S, Tian Y, Wang Y, Qin Z, Doi S, Xu C.   +6 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

How to Evaluate Hospital Care in the Dying Phase-Development of a Data Extraction Tool for Retrospective Medical Record Analysis. [PDF]

J Eval Clin Pract
Kaur S, Meesters S, Schieferdecker A, Dangendorf A, Strohbücker B, Oubaid N, Ullrich A, Milke V, Oechsle K, Schulz H, Voltz R, Kremeike K.   +11 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

From data extraction to analysis: a comparative study of ELISE capabilities in scientific literature. [PDF]

Front Artif Intell
Gobin M, Gosnat M, Toure S, Faik L, Belafa J, Villedieu de Torcy A, Armstrong F.   +6 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Evaluating a Customized Version of ChatGPT for Systematic Review Data Extraction in Health Research: Development and Usability Study. [PDF]

JMIR Form Res
Sercombe J, Bryant Z, Wilson J.
europepmc   +1 more source