Results 51 to 60 of about 1,950,388 (266)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Data Extractions Using a Large Language Model (Elicit) and Human Reviewers in Randomized Controlled Trials: A Systematic Comparison

Cochrane Evidence Synthesis and Methods
Aim We aimed at comparing data extractions from randomized controlled trials by using Elicit and human reviewers. Background Elicit is an artificial intelligence tool which may automate specific steps in conducting systematic reviews. However, the tool's
Joleen Bianchi, Julian Hirt, Magdalena Vogt, Janine Vetsch   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Using Artificial Intelligence Tools as Second Reviewers for Data Extraction in Systematic Reviews: A Performance Comparison of Two AI Tools Against Human Reviewers

Cochrane Evidence Synthesis and Methods
Background Systematic reviews are essential but time‐consuming and expensive. Large language models (LLMs) and artificial intelligence (AI) tools could potentially automate data extraction, but no comprehensive workflow has been tested for different ...
T. Helms Andersen, T. M. Marcussen, A. D. Termannsen, T. W. H. Lawaetz, O. Nørgaard   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Digital Presentation of Bulgarian Language Heritage - Tools and Web-applications

Digital Presentation and Preservation of Cultural and Scientific Heritage, 2016
The article describes a model of integrating language techniques with leading-edge technology to develop a web-based on-line tool for heritage language preservation and e-learning.
Ralitsa Dutsova
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Automated Assessment Tool for 3D Computer-Aided Design Models

Applied Sciences
Computer-aided design (CAD) has become an integral part of engineering education, particularly for those studying mechanical engineering. By providing practical skills that are highly valued in the engineering industry, proficiency in CAD systems ...
Ameni Eltaief, Sabrine Ben Amor, Borhen Louhichi, Nashmi H. Alrasheedi, Abdennour Seibi   +4 more
doaj   +1 more source

Adaptive Web Data Extraction Policies

Eighth IEEE International Workshop on Policies for Distributed Systems and Networks (POLICY'07), 2007
Web data extraction is concerned, among other things, with routine data accessing and downloading from continuously-updated dynamic Web pages. There is a relevant trade-off between the rate at which the external Web sites are accessed and the computational burden on the accessing client.
FIUMARA, Giacomo, MARCHI M, PROVETTI A.
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source