Results 121 to 130 of about 5,283,237 (295)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Enhancing Industry 4.0 Energy Efficiency: A Data-Driven Dynamic Control for Pull-Flow Lines
Applied SciencesThis paper investigates the effectiveness of dynamic switch-off policies in flow line production systems, aiming to balance energy efficiency and operational performance.
Paolo Renna
doaj +1 more source
Valve, normally closed, titanium Pyronetics model 1426 [PDF]
Performance tests of the explosive actuated, normally closed titanium valve 1426, are outlined. The valves are used to control hydrazine flow in a monopropellant thruster. Data cover pressure tests, internal and external leakage tests, flow control tests,
Avalos, E.
core +1 more source
Getting in control of your control flow with control-data isolation [PDF]
2015 IEEE/ACM International Symposium on Code Generation and Optimization (CGO), 2015 William Arthur +3 more
openaire +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
To parallelize or not to parallelize, control and data flow issue
CoRR, 2013 New trends towards multiple core processors imply using standard programming models to develop efficient, reliable and portable programs for distributed memory multiprocessors and workstation PC clusters. Message passing using MPI is widely used to write efficient, reliable and portable applications.
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Enhancing Data Flow Tracking for Data Usage Control.
, 2020 This thesis provides a new, hybrid approach in the field of Distributed Data Usage Control (DUC), to track the flow of data inside applications. A combination between static information flow analysis and dynamic data flow tracking enables to track selectively only those program locations that are actually relevant for a flow of data.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source