Results 121 to 130 of about 28,387,539 (314)

Pathways to suicide prevention: a population-based cohort study of the mediating role of Bolsa Família in psychosocial stressors in the 100 million Brazilian cohort

BMJ Public Health
Introduction Suicide is a major public health concern in Brazil, and its risk is heightened by psychosocial stressors disproportionately affecting socioeconomically vulnerable groups.
Maurício Lima Barreto, Flávia Jôse Oliveira Alves, Patrícia Fortes Cavalcanti de Macêdo, Gilciane Ceolin, Rumenick Pereira Silva, Luis F S Castro-de-Araujo, Daiane B Machado   +6 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Combining machine learning and dynamic system techniques to early detection of respiratory outbreaks in routinely collected primary healthcare records

BMC Medical Research Methodology
Background Methods that enable early outbreak detection represent powerful tools in epidemiological surveillance, allowing adequate planning and timely response to disease surges.
Dérick G. F. Borges, Eluã R. Coutinho, Thiago Cerqueira-Silva, Malú Grave, Adriano O. Vasconcelos, Luiz Landau, Alvaro L. G. A. Coutinho, Pablo Ivan P. Ramos, Manoel Barral-Netto, Suani T. R. Pinho, Marcos E. Barreto, Roberto F. S. Andrade   +11 more
doaj   +1 more source

Rapid weight gain in first 2 years of life and BMI trajectories from 3 to <10 years: a population-based longitudinal study of 1.7 million Brazilian childrenResearch in context

The Lancet Regional Health. Americas
Summary: Background: Obesity is considered a disease with negative health impacts at all life stages. Changes in growth patterns, such as postnatal rapid weight gain (RWG), can be important predictors of growth trajectories in children.
Carolina Santiago-Vieira, Leah Li, Rita de Cássia Ribeiro Silva, Juliana Freitas de Mello e Silva, Enny S. Paixão, Maurício L. Barreto, Gustavo Velasquez-Melendez   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Disparities in stillbirth rates according to municipal deprivation levels: a nationwide study in Brazil

BMC Pregnancy and Childbirth
Background Investigating the relationship between stillbirth and deprivation is essential to guide healthcare improvements, as evidence is scarce in LMIC contexts.
Ismina Papadhima, Lays Janaina Prazeres Marques, Elzo Pereira Pinto, Hannah Blencowe, Marcia Furquim de Almeida, Maria Yury Ichihara, Mauricio L. Barreto, Enny S. Paixao   +7 more
doaj   +1 more source

Ethno-racial inequalities on adverse birth and neonatal outcomes: a nationwide, retrospective cohort study of 21 million Brazilian newbornsResearch in context

The Lancet Regional Health. Americas
Summary: Background: Ethno-racial inequalities are critical determinants of health outcomes. We quantified ethnic-racial inequalities on adverse birth outcomes and early neonatal mortality in Brazil.
Poliana Rebouças, Enny S. Paixão, Dandara Ramos, Julia Pescarini, Elzo Pereira Pinto-Junior, Ila R. Falcão, Maria Yury Ichihara, Samila Sena, Rafael Veiga, Rita Ribeiro, Laura C. Rodrigues, Maurício L. Barreto, Emanuelle F. Goes   +12 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source