Results 151 to 160 of about 4,962,296 (289)

A New Approach to Large Multiomics Data Integration. [PDF]

Anal Chem
Dexter A, Thomas SA, Steven RT, Robinson KN, Taylor AJ, Elia EA, Nikula C, Campbell AD, Panina Y, Najumudeen AK, Yan B, Grabowski P, Hamm G, Swales J, Tripp A, Poulogiannis G, Yuneva MO, Barry S, Goodwin RJA, Sansom OJ, Takats Z, Bunch J.   +21 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

MULTI-OBJECT DATA INTEGRATION IN THE STUDY OF PRIMARY PROGRESSIVE APHASIA. [PDF]

Ann Appl Stat
Gutierrez R, Scheffler A, Guhaniyogi R, Gorno-Tempini ML, Mandelli ML, Battistella G.   +5 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

<i>parsomics</i>: a data-driven framework for metagenomics data integration powered by a local relational database. [PDF]

Bioinform Adv
de Azevedo PS, Vedovatto MM, de Freitas PCG, Luz RBS, Streit RSA, Persinoti GF.   +5 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Integrating data [PDF]

Nature Methods, 2012
Nils Gehlenborg, Bang Wong
openaire   +1 more source

FKG-MM: A multi-modal fuzzy knowledge graph with data integration in healthcare. [PDF]

PLoS One
Tan NH, Tuan TM, Chuan PM, Hoang ND, Thanh LQ, Son LH.   +5 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Advancing the modernization of traditional Chinese medicine through artificial intelligence and multimodal data integration. [PDF]

Chin Med
Guo P, Jiang M, Hu S, Jiang Q, Li L, Wu J, Ma Y, Wu Z.   +7 more
europepmc   +1 more source