Results 71 to 80 of about 28,387,539 (314)

Public engagement with science: an inclusive approach to innovate in health research with real-world data

BMC Medical Research Methodology
Background Public engagement with science (PES) initiatives in health research that use big data to analyze social inequalities in health requires strategies and methods adapted to the contexts of countries in the Global South. This paper aims to examine
Adalton dos Anjos Fonseca, Valentina Martufi, Walisson Angélico de Araújo, Denise Moraes Pimenta, Acácia Mayra Pereira de Lima, Juliana Araújo Prata de Faria, Danilo Luis Cerqueira Dias, Eduarda Ferreira dos Anjos, Maria del Pillar Flores Quispe, Gisela Rodrigues Piloto, Vivian Mitiko Queiroz Lima, Felipe Ferré, Marcos Antônio Gêmeos Almeida Sampaio, Erika de Souza Lopes, Blanda Helena de Mello, Diego Cavalcante Teixeira Daltro, Mariana Rodrigues Sebastião de Almeida, Raiza Tourinho Lima, Elzo Pereira Pinto Junior, Mauricio L. Barreto, Maria Yury T. Ichihara   +20 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Wildfire, deforestation and health in tropical rainforest areas: a scoping review protocol

BMJ Open
Introduction Wildfires and deforestation potentially have direct effects on multiple health outcomes as well as indirect consequences for climate change. Tropical rainforest areas are characterised by high rainfall, humidity and temperature, and they are
Mauricio L Barreto, Michal Shimonovich, Julia Pescarini, Jonathan R Olsen, Philip Cooper, Taísa Rodrigues Cortes, Lucas Emanuel, Nathalia Sernizon Guimarães, Valerie Wells, Gustavo Casais, Poliana Rebouças de Magalhães, José Firmino de Sousa Filho, Danielson Jorge Delgado Neves, Edgar Marcelino de Carvalho Neto, Roberto F S Andrade, Gervasio Ferreira dos Santos   +15 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Evaluating the relationship between conditional cash transfer programme on preterm births: a retrospective longitudinal study using the 100 million Brazilian cohort

BMC Public Health
Background Preterm births increase mortality and morbidity during childhood and later life, which is closely associated with poverty and the quality of prenatal care.
Naiá Ortelan, Márcia Furquim de Almeida, Elzo Pereira Pinto Júnior, Nivea Bispo, Rosemeire L. Fiaccone, Ila Rocha Falcão, Aline dos Santos Rocha, Dandara Ramos, Enny S. Paixão, Rita de Cássia Ribeiro-Silva, Laura C. Rodrigues, Mauricio L. Barreto, Maria Yury T. Ichihara   +12 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mediated data integration and transformation for web service-based software architectures [PDF]

, 2006
Service-oriented architecture using XML-based web services has been widely accepted by many organisations as the standard infrastructure to integrate heterogeneous and autonomous data sources.
Zhu, Yaoling, Pahl, Claus
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source