Results 81 to 90 of about 4,962,296 (289)
Integration of linked open data in case-based reasoning systems [PDF]
, 2010 This paper discusses the opportunities of integrating Linked Open Data (LOD) resources into Case-Based Reasoning (CBR) systems. Upon the application domain travel medicine, we will exemplify how LOD can be used to fill three out of four knowledge ...
Althoff, Klaus-Dieter +2 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Provenance in Linked Data Integration
, 2010 The open world of the (Semantic) Web is a global information space offering diverse materials of disparate qualities, and the opportunity to re-use, aggregate, and integrate these materials in novel ways. The advent of Linked Data brings the potential to
Gibbins, Nicholas +2 more
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
npj Digital MedicineInfectious disease specialists (IDS) improve outcomes of patients with Staphylococcus bacteremia, but immediate IDS access is not always guaranteed. We investigated whether a care-integrated computerized decision support system (CDSS) can safely enhance ...
Julia Palm +50 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Increasing the Usability of the American Time Use Survey: IPUMS ATUS
DataThis paper describes IPUMS ATUS, which simplifies the use of time diary data by disseminating a harmonized and enhanced version of the American Time Use Survey (ATUS).
Kari C. W. Williams +3 more
doaj +1 more source
Extraction of Maritime Road Networks From Large-Scale AIS Data
IEEE Access, 2019 Extracting road network information including lane boundaries, lane centerlines, junctions and their relationship from AIS data plays an important role in location based services, urban computing and intelligent transportation systems, etc.
Guiling Wang, Jinlong Meng, Yanbo Han
doaj +1 more source