Results 71 to 80 of about 25,395,562 (249)

GeoLedger: blockchain and GIS architecture for trusted emergency incident mapping

open access: yesFrontiers in Blockchain
Most existing emergency management systems are centralized, leaving critical information vulnerable to unauthorized access, manipulation, and single points of failure.
Osama A. Khashan
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A Layered Governance Coverage Model for Decentralized Autonomous Organizations: Formalization, Empirical Analysis, and Implications for Blockchain-Based IoT/AI Systems

open access: yesInformation
Decentralized Autonomous Organizations (DAOs) enable blockchain-based collective governance, yet existing studies often evaluate DAO governance through isolated mechanisms, particularly voting systems.
Abeer S. Al-Humaimeedy, Rand Alkharashi
doaj   +1 more source

A Secure-Enhanced Data Aggregation Based on ECC in Wireless Sensor Networks

open access: yesSensors, 2014
Data aggregation is an important technique for reducing the energy consumption of sensor nodes in wireless sensor networks (WSNs). However, compromised aggregators may forge false values as the aggregated results of their child nodes in order to conduct ...
Qiang Zhou, Geng Yang, Liwen He
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Enabling Fault-Tolerant and Load-Balanced Multi-Query Searchable Encryption With Multi-Level Revocation in Edge-Fog-Cloud for Electronic Health Records

open access: yesIEEE Open Journal of the Communications Society
Secure and efficient data sharing in Internet of Things (IoT)–based Electronic Health Record (IoT-EHR) systems remains challenging due to heterogeneous query types, dynamic user revocation, and the massive volume of continuously generated data. In
Maneesha Perera, Somchart Fugkeaw
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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