Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Phenomenological approach to scatterometer data interpretation [PDF]
A graphic method of analyzing radar scatterometer sea clutter data leading to linear relations between scattering cross sections and tan angle of incidence of the radiation is proposed.
Alzofon, F. E.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Precautions for study design and data interpretation of clinical metabolomics. [PDF]
Proc Natl Acad Sci U S A, 2022 Zheng J, Wang K, Wang Y, Li K.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Tutorial on Bonferroni Correction as a Post Hoc Analysis of a Significant Chi-Squared Test: A Methodological Guide in Food Science [PDF]
Journal of Food Quality and Hazards ControlBackground: In medical research, analyzing the relationship between two categorical variables is common. While chi-square tests (e.g., Pearson's, McNemar's, and Cochran-Mantel-Haenszel) can determine if a significant association exists, they do not ...
F. Madadizadeh, M. Abdoli
doaj
Human in vivo medial gastrocnemius gear during active and passive muscle lengthening: effect of inconsistent methods and nomenclature on data interpretation. [PDF]
Biol Open, 2023 Pinto MD +3 more
europepmc +1 more source
, 2018 This paper continues the discussion of the representation of ontologies in the first-order logical environment FOLE. According to Gruber, an ontology defines the primitives with which to model the knowledge resources for a community of discourse.
Kent, Robert E.
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Bridging neuromorphic computing and deep learning for next-generation neural data interpretation. [PDF]
Front Comput NeurosciZhang M, Wang T, Zhu Z.
europepmc +1 more source