Results 161 to 170 of about 28,602,314 (397)

Making sense of shaky data in humanitarian crises

open access: yesFrontiers in Public Health
Humanitarian decision-making occurs in volatile and politically charged environments where information is often incomplete, outdated, or conflicting. Effective humanitarian response often requires interpreting poor-quality data to guide interventions ...
Sandro Colombo   +2 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

Measuring. Monitoring. Management. Control

open access: yesИзмерение, мониторинг, управление, контроль
Background. The emergence and importance of the research topic is substantiated by the colossal growth in the volume of accumulated and underprocessed medical information, the evolution of mathematical and algorithmic apparatus, and the need to improve
M.V. Sprindzuk   +2 more
doaj   +1 more source

Targeted proteomics data interpretation with DeepMRM. [PDF]

open access: yesCell Rep Methods, 2023
Park J   +9 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

open access: yesMolecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza   +3 more
wiley   +1 more source

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