Results 121 to 130 of about 593,692 (308)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Data Note: Alternative Name Encodings - Using Jyutping or Pinyin as tonal representations of Chinese names for data linkage

International Journal of Population Data Science
Accurate data linkage across large administrative databases is crucial for addressing complex research and policy questions, yet linkage errors - stemming from inconsistent name representations - can introduce biases, predominantly for names not given ...
Joseph Lam, Mario Cortina-Borja, Rob Aldridge, Ruth Blackburn, Katie Harron   +4 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Data linkage in social care: a pilot project

International Journal of Population Data Science, 2017
ABSTRACT Background To build the complete picture of service provision there is a need to broaden the linked data available to include health, social service provision by Local Authorities, and provision of support by third sector organisations. Data Linkage in Social Care is a pilot project to test the feasibility of linking datasets from a local ...
Orrell, Alison, Heaven, Martin, Seddon, Diane, Robinson, Catherine; id_orcid 0000-0001-7240-7107   +3 more
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Probabilistic record linkage and an automated procedure to minimize the undecided-matched pair problem [PDF]

Probabilistic record linkage allows the assembling of information from different data sources. In this article, we present a procedure in case a one-to-one relationship between records in different files is expected but is not found only by applying the ...
Kenneth Hill, Carla Jorge Machado
core  

Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms

, 2009
A genomewide linkage scan was carried out in eight clinical samples of informative schizophrenia families. After all quality control checks, the analysis of 707 European-ancestry families included 1615 affected and 1602 unaffected genotyped individuals ...
D Walsh, Gejman, P. V., D F Levinson, Alexander, M., Ribble, R, Mallet, J., Wormley, B., Godard, S, O'Neill, A., Dikeos, D., Alexander, M, Owen, Michael John, F B Lerer, Holmans, PA, Wormley, B, O'Donovan, MC, Liang, KY, R R Crowe, Norton, N., Jay, M., Nertney, D., Silverman, J. M., Levinson, D. F., Mowry, Bryan, Sanders, A. R., Nestadt, G., P A Holmans, Walsh, D., Pulver, A. E., V K Lasseter, Laurent, C, Kendler, K. S., A O'Neill, A E Pulver, C Laurent, Holmans, Peter Alan, G Nestadt, M J Owen, M Alexander, Holmans, P. A., O'Donovan, Michael Conlon, D B Wildenauer, Albus, M., O'Neill, Anthony, Norton, N, P V Gejman, Gejman, PV, Wildenauer, DB, M Albus, Maier, W, Williams, N. M., Nestadt, G, Schwab, SG, G Papadimitriou, Nertney, D, Papadimitriou, G, Lasseter, V. K., D Nertney, Liang, K. Y., Lerer, F. B., Lasseter, VK, O'Donovan, M. C., Duan, J., K S Kendler, Mallet, J, O'Neill, A, N M Williams, J Duan, Mowry, B. J., Duan, J, B Riley, D Dikeos, Owen, M. J., M C O'Donovan, B J Mowry, J Mallet, Owen, MJ, Laurent, C., Norton, Nadine, Jay, M, Crowe, R. R., B Wormley, Maier, W., Albus, M, Walsh, D, R Ribble, Schwab, S. G., S G Schwab, S Godard, N Norton, W Maier, Papadimitriou, G., M Jay, Riley, B, Williams, Nigel Melville, Kendler, KS, Williams, NM, A R Sanders, Lerer, FB, Riley, B., K Y Liang, Pulver, AE, Sanders, AR, Godard, S., Ribble, R., Wildenauer, D. B., J M Silverman   +106 more
core   +1 more source

Ethnic bias in data linkage

The Lancet Digital Health, 2021
Louise Mc Grath-Lone, Nicolás Libuy, David Etoori, Ruth Blackburn, Ruth Gilbert, Katie Harron   +5 more
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source