Results 111 to 120 of about 24,315,328 (294)

The NT data linkage study

, 2018
This chapter describes the origins of the NT Data Linkage Study to investigate the early child development educational and wellbeing outcomes of all children born in the Northern Territory over the 20-year period since 1994.
Lynch , John, Walter, Maggie, Schurer, Stepfanie, Brimblecombe, Julie, Shaw, Peter, Guthridge, Steven, Midford, Richard, Bodkin-Andrews, Gawaian (R10937), Silburn, Sven   +8 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

End-stage renal disease and survival in people with diabetes : a national database linkage study [PDF]

, 2014
© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. Funding This work was supported by the Wellcome Trust through the Scottish Health Informatics Programme (SHIP).
W. Metcalfe, Conway, B., Bell, S, H. C. Looker, D. Levin, Joss, N., Colhoun, H. M., Sattar, N, McKnight, J, N. Joss, Traynor, J. P., Wild, S.; id_orcid, S. Livingstone, Brady, I, J. P. Traynor, Fletcher, E H, Leese, G., Levin, D, Looker, H C, ?, ?, Lindsay, R. S., Pearson, D., Joss, N, Brady, I., Lindsay, R S, Scottish Diabetes Research Network and Scottish Renal Registry, Colhoun, H M, Wild, S, S. Wild, McKnight, J., B. Conway, Livingstone, S., Sattar, N., J. Mcknight, Traynor, J P, Wild, S., N. Halbesma, Pearson, D, Levin, D., N. Sattar, D. Pearson, Leese, G, Halbesma, N, Halbesma, N., Metcalfe, W, Livingstone, S, Looker, H. C., Bell, S., R. S. Lindsay, Philip, S, I. Brady, S. Bell, G. Leese, Bell, S.; id_orcid, Metcalfe, W., Conway, B, Philip, S., S. Philip, E. H. Fletcher, Fletcher, E. H.   +59 more
core   +1 more source

Data linkage algebra, data linkage dynamics, and priority rewriting

, 2008
We introduce an algebra of data linkages. Data linkages are intended for modelling the states of computations in which dynamic data structures are involved. We present a simple model of computation in which states of computations are modelled as data linkages and state changes take place by means of certain actions.
Bergstra, J.A., Middelburg, C.A.
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Data Note: Alternative Name Encodings - Using Jyutping or Pinyin as tonal representations of Chinese names for data linkage

International Journal of Population Data Science
Accurate data linkage across large administrative databases is crucial for addressing complex research and policy questions, yet linkage errors - stemming from inconsistent name representations - can introduce biases, predominantly for names not given ...
Joseph Lam, Mario Cortina-Borja, Rob Aldridge, Ruth Blackburn, Katie Harron   +4 more
doaj   +1 more source

Data linkage in social care: a pilot project

International Journal of Population Data Science, 2017
ABSTRACT Background To build the complete picture of service provision there is a need to broaden the linked data available to include health, social service provision by Local Authorities, and provision of support by third sector organisations. Data Linkage in Social Care is a pilot project to test the feasibility of linking datasets from a local ...
Orrell, Alison, Heaven, Martin, Seddon, Diane, Robinson, Catherine; id_orcid 0000-0001-7240-7107   +3 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source