Results 91 to 100 of about 593,692 (308)

Information Leakage in Data Linkage

CoRR
The process of linking databases that contain sensitive information about individuals across organisations is an increasingly common requirement in the health and social science research domains, as well as with governments and businesses. To protect personal data, protocols have been developed to limit the leakage of sensitive information. Furthermore,
Peter Christen, Rainer Schnell, Anushka Vidanage   +2 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Report on the use of linked data relating to Aboriginal and Torres Strait Islander people [PDF]

, 2013
The Council of Australian Governments funded the Australian Institute of Health and Welfare and the Australian Bureau of Statistics to review past, ongoing and planned data linkage studies that have an Indigenous focus.

core  

Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2 [PDF]

, 2005
Background: In order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study.Methods: DNA from eighteen families, densely affected by alcoholism, was used to genotype a set of polymorphic ...
Devitgh, Audrey, Kest, Wendy, Kest Wendy, Devitgh, A, McQuillin Andrew, Cook Christopher CH, McQuillin, Andrew, Gurling Hugh MD, Curtis, David, Gurling, Hugh M.D., Cook, Christopher C.H., Devitgh Audrey, Gurling, HMD, Guerrini, Irene, Curtis, D, Curtis David, McQuillin, A, Guerrini, I, Cook, CCH, Guerrini Irene, Kest, W   +20 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

End-stage renal disease and survival in people with diabetes : a national database linkage study [PDF]

, 2014
© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. Funding This work was supported by the Wellcome Trust through the Scottish Health Informatics Programme (SHIP).
W. Metcalfe, Conway, B., Bell, S, H. C. Looker, D. Levin, Joss, N., Colhoun, H. M., Sattar, N, McKnight, J, N. Joss, Traynor, J. P., Wild, S.; id_orcid, S. Livingstone, Brady, I, J. P. Traynor, Fletcher, E H, Leese, G., Levin, D, Looker, H C, ?, ?, Lindsay, R. S., Pearson, D., Joss, N, Brady, I., Lindsay, R S, Scottish Diabetes Research Network and Scottish Renal Registry, Colhoun, H M, Wild, S, S. Wild, McKnight, J., B. Conway, Livingstone, S., Sattar, N., J. Mcknight, Traynor, J P, Wild, S., N. Halbesma, Pearson, D, Levin, D., N. Sattar, D. Pearson, Leese, G, Halbesma, N, Halbesma, N., Metcalfe, W, Livingstone, S, Looker, H. C., Bell, S., R. S. Lindsay, Philip, S, I. Brady, S. Bell, G. Leese, Bell, S.; id_orcid, Metcalfe, W., Conway, B, Philip, S., S. Philip, E. H. Fletcher, Fletcher, E. H.   +59 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Queensland Cardiovascular Data Linkage (QCard): A population-based cohort study

, 2020
Queensland is Australia's hotspot for cardiovascular disease (CVD). Critically, beyond modifiable lifestyle risk factors; socio-demographic differences and environmental factors account for significant variations in healthcare use and outcomes among ...
Scuffham, Paul A, Nghiem, Son, Afoakwah, Clifford, Byrnes, Joshua   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source