Results 81 to 90 of about 24,315,328 (294)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A novel protocol for a "Citizen Panel" for diverse Public and Participant Involvement in the review and development of the process to access data in the UK Longitudinal Linkage Collaboration Trusted Research Environment

International Journal of Population Data Science
Background Researchers can apply to UK Longitudinal Linkage Collaboration (UK LLC) to access Longitudinal Population Study (LPS) data linked to health, non-health administrative and geo-environmental data.
Lidis Garbovan, Betty O. Idemudia, Robin Flaig, Kirsteen Campbell, Katharine Evans, Andy Boyd, Sarah Cunningham-Burley, Emma L. Turner   +7 more
doaj   +1 more source

Identifying children with Cystic Fibrosis in population-scale routinely collected data in Wales

International Journal of Population Data Science, 2020
Introduction The challenges in identifying a cohort of people with a rare condition can be addressed by routinely collected, population-scale electronic health record (eHR) data, which provide large volumes of data at a national level.
Rowena Griffiths, Daniela K Schlüter, Ashley Akbari, Rebecca Cosgriff, David Tucker, David Taylor-Robinson   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Co-development and Adoption of Transparency in Data Access Standards: Process, Implementation, and Impact

International Journal of Population Data Science
Objectives This initiative aimed to enhance transparency in health data access processes by co-developing and implementing clear standards. The goal was to improve public trust and understanding, streamline governance, and promote meaningful public ...
Ester Bellavia, Alan Holcroft, Yemi Macaulay, Doreen Tembo, Cassie Smith, Andy Boyd   +5 more
doaj   +1 more source

Demystifying probabilistic linkage

International Journal of Population Data Science, 2018
Many of the distinctions made between probabilistic and deterministic linkage are misleading. While these two approaches to record linkage operate in different ways and can produce different outputs, the distinctions between them are more a result of how
James C Doidge, Katie Harron
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

LINKAGE AND DUALITY OF MODULES [PDF]

, 2009
Martsinkovsky and Strooker [13] recently introduced module theoretic linkage using syzygy and transpose. This generalization brings possibility of much application of linkage, especially, to homological theory of modules. In the present paper, we connect
Nishida, Kenji, Kenji Nishida
core   +1 more source

Phenotyping data for "Linkage mapping of biomass production and composition traits in a Miscanthus sinensis population"

, 2022
Phenotyping data for "Linkage mapping of biomass production and composition traits in a Miscanthus sinensis ...
Arnoult, Stéphanie, Bodineau, Guillaume, Volant, Solenne, Mignot, Emilie, Raverdy, Raphaël, Griveau, Yves, Brancourt-Hulmel, Maryse, Fingar, Laura   +7 more
core   +1 more source

Embedding Public Voices in Data Governance: Insights from the GUARDS Principles Consultation

International Journal of Population Data Science
Objectives This project explored public perspectives on the GUARDS Principles, an overarching governance framework for the population data research community, which builds on existing good practice guidance.
Ester Bellavia, Rachel Brophy, Sonia Patton, Doreen Tembo, Cassie Smith, Andy Boyd   +5 more
doaj   +1 more source