Results 141 to 150 of about 25,746,555 (330)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

US-Japan Data Linkage.

Kakuyūgō kenkyū, 1985
Initial testing of the US-Japan Data Link has proceeded and the entire system is approaching operational status. An overview of the technical structure of the linkage is given. The file transport and interactive terminal capabilities are discussed and specific example are included. Some considerations of the initial use and scope of allowed activities,
Tetsuo Kamimura, Yoshihiko Abe, Hideo Ikegami   +2 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Data Note: Alternative Name Encodings - Using Jyutping or Pinyin as tonal representations of Chinese names for data linkage

International Journal of Population Data Science
Accurate data linkage across large administrative databases is crucial for addressing complex research and policy questions, yet linkage errors - stemming from inconsistent name representations - can introduce biases, predominantly for names not given ...
Joseph Lam, Mario Cortina-Borja, Rob Aldridge, Ruth Blackburn, Katie Harron   +4 more
doaj   +1 more source

On the framing of patent citations and academic paper citations in refl ecting knowledge linkage: A discussion of the discrepancy of their divergent value-orientations [PDF]

, 2010
It has been widely recognized that academic paper citations will reflect scientific knowledge linkage. Patent citations are similar to academic paper citations in many aspects: Citation frequency distribution is often skewed; citation frequency varies ...
LI Rui, Li Rui (E-mail: lirui@mail.las.ac.cn), MENG Liansheng   +2 more
core  

Data linkage algebra, data linkage dynamics, and priority rewriting

, 2008
We introduce an algebra of data linkages. Data linkages are intended for modelling the states of computations in which dynamic data structures are involved. We present a simple model of computation in which states of computations are modelled as data linkages and state changes take place by means of certain actions.
Bergstra, J.A., Middelburg, C.A.
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Multinationals and Linkages: An Empirical Investigation [PDF]

Several recent papers have used plant-level data and panel econometric techniques to carefully explore the existence FDI externalities. One conclusion that emerges from this literature is that it is difficult to find evidence of positive externalities ...
Andres Rodriguez-Clare, Laura Alfaro
core