Results 181 to 190 of about 1,251,881 (338)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Post Capsule Endoscopy Small Bowel Cancer Rate-An Australian Data Linkage Analysis. [PDF]

J Gastrointest Cancer
Hoey P, Goetz N, Ryan K, Appleyard M, Grimpen F.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Probabilistic data linkage to study the epidemiology of unintentional fatal drowning in a large metropolitan region. [PDF]

Inj Epidemiol
Shenoi RP, Levine N, Camp EA, Nguyen L, McKay S, Zaman S.   +5 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Remote Consultations in England During COVID-19: Challenges in Data Quality, Linkage, and Research Validity

Liliana Hidalgo-Padilla, M. Dabbous, Kristoffer Halvorsrud, Thomas Beaney, Gideon Gideon, Eoin Gogarty, Geva Greenfield, Benedict Hayhoe, Gabriele Kerr, Rosalind Raine, Nirandeep Rehill, Robert Stewart, Fiona Gaughran, Mariana Pinto da Costa   +13 more
openalex   +1 more source

Describing the Linkages of the Citizenship and Immigration Canada Permanent Resident Data and Vital Statistics—Death Registry to Ontario’s Administrative Health Database

, 2017
Astrid Guttmann, Maria Chiu, Michael Lebenbaum, Kelvin Lam, Nelson W. Chong, Mahmoud Azimaee, Karey Iron, Douglas G. Manuel   +7 more
openalex   +2 more sources

Linking Electronic Health Record and Trauma Registry Data: Assessing the Value of Probabilistic Linkage [PDF]

, 2018
Ashimiyu Durojaiye, Lisa Puett, Scott R. Levin, Matthew Toerper, Nicolette McGeorge, Kristen Webster, Gurmehar Deol, Hadi Kharrazi, Harold P. Lehmann, Ayşe P. Gürses   +9 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source