Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Referral compliance and subsequent hospital admissions for COPD and cardiovascular disease in the Netherlands: a data linkage study. [PDF]
BMC Health Serv ResDros JT +4 more
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The Rate of Procedures Required to Maintain Hemodialysis Vascular Access: A Data Linkage Analysis. [PDF]
Kidney360Richards KG +7 more
europepmc +1 more source
Linkage Between Neurological Registry Data and Administrative Data [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2013 Jette, Nathalie +16 more
openaire +3 more sources
Hierarchical Cluster Analysis: Comparison of Three Linkage Measures and Application to Psychological Data [PDF]
, 2015 Odilia Yim, Kylee T. Ramdeen
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Procedure-level data linkage to drive improvement in case ascertainment for the Australian Breast Device Registry. [PDF]
Health Inf ManagHerbert D +7 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source