Results 221 to 230 of about 1,251,881 (338)

Coagulation and Transfusion Informatics in Chronic Liver Disease: A Data Linkage Study of Emergency Department Presentations. [PDF]

EJHaem
Latona A, Smith E, Grant J, Mitra B.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Health inequalities and trends in heart failure diagnosis in primary care in England, 2000-21: a national retrospective cohort data-linkage study. [PDF]

Lancet Prim Care
Lawson CA, Ali MR, McCann GP, Squire I, Zaccardi F, Rashid M, Barber K, Alaei Kalajahi R, Miller CA, Williams R, Clark AL, Petrie MC, Taylor CJ, Friday JM, Conrad N, Cleland JGF, Khunti K.   +16 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Long-term adherence to glucose-lowering medications in adults with diabetes: A data linkage study. [PDF]

Diabetes Obes Metab
Lee CMY, Gibson AA, Nassar N, Colagiuri S.   +3 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Correction: Contact with child protection services during pregnancy: a cross-sectional study using the eLIXIR born in South London, UK maternity-child data linkage. [PDF]

BMC Pregnancy Childbirth
De Backer K, Seed P, Burton S, Montgomery E, Sandall J, eLIXIR-Born in South London Partnership, Easter A.   +6 more
europepmc   +1 more source

The Value of Total Knee Replacement in the UK: A Strategy for a National Data- Linkage and Cost-Effectiveness Study on Obesity and Healthcare Access

Reuben Ansah-Sarpong, Mbbs
openalex   +1 more source

New Jersey's Response to the Call for Firefighter Cancer Data: Creating a Retrospective Cohort to Study Cancer Mortality among New Jersey Firefighters through Data Linkages and an Honest Broker. [PDF]

, 2022
Antoinette M. Stroup, Gerald Harris, Matthew W. Wilson, Taylor M. Black, Judith M. Graber   +4 more
openalex