Results 251 to 260 of about 1,251,881 (338)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

The START clinic: An observational feasibility study of prospective obstetric research with retrospective ART data linkage

open access: yes
Coucill M   +7 more
europepmc   +1 more source

The United States' Early Experience With Lung Cancer Screening-Creation of a National Data Linkage: A Brief Report. [PDF]

open access: yesJTO Clin Res Rep
Doria-Rose VP   +14 more
europepmc   +1 more source

Tool for data linkage

open access: yes
Develop a tool that facilitates and partly automatizes data linkages. A tool (for example in R, or Py-thon) will be build. Based on substantial choices made by the researchers, the tool facilitates combin-ing datasets.
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Improving opportunities for data linkage within Children Looked After administrative records in Wales. [PDF]

open access: yesInt J Popul Data Sci
Bailey GA   +9 more
europepmc   +1 more source

Further Data on Linkage in Rabbits [PDF]

open access: yesProceedings of the National Academy of Sciences, 1936
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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