Results 101 to 110 of about 891,248 (273)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Distortion Measurement Metric for Human Image Refinement and Evaluation Using Distorted Image Datasets

IEEE Access
This paper introduces novel evaluation metrics for quantifying distortion in human image retouching and presents a COCO-based retouched image dataset to validate their effectiveness.
Gwangyeol Yu, Kyungseo Yoon, Sangwoo Lee, Yeju Shin, Jonghyuk Park   +4 more
doaj   +1 more source

Case Management: a data set of definitions [PDF]

arXiv, 2015
Knowledge-intensive processes (KiPs) are becoming increasingly important for organizations with the rise of the knowledge society. Due to their unpredictable and emergent characteristic worklfow management solutions are not suitable to support KiPs.
arxiv  

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Dynamic analysis of a novel hyperchaotic system based on STM32 and application in image encryption

Scientific Reports
This paper presents a novel 4D hyperchaotic system derived from a modified 3D Lorenz chaotic system. A key aspect of this system is the presence of a single equilibrium point, and its stability is carefully analyzed. The dynamic properties, including the
XueFeng Cheng, Hongmei Zhu, Lian Liu, Kunpeng Mao, Juan Liu   +4 more
doaj   +1 more source

Can Agricultural Industry Integration Reduce the Rural–Urban Income Gap? Evidence from County-Level Data in China

Land
The improvement in urban production efficiency has led to income distribution being skewed towards urban labor, thereby widening the urban–rural income gap.
Xiaoli Chen, Zhefeng Huang, Chaoguang Luo, Zhineng Hu   +3 more
doaj   +1 more source

Survey of progress and trend of development and use of automatic data processing in business and management control systems of the Federal Government, as of December 1957—III [PDF]

, 1959

openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Contributions of PDM Systems in Organizational Technical Data Management [PDF]

arXiv, 2010
Product Data Management (PDM) claims of producing desktop and web based systems to maintain the organizational data to increase the quality of products by improving the process of development, business process flows, change management, product structure management, project tracking and resource planning.
arxiv