Results 161 to 170 of about 10,498,042 (356)

Policy texts and actions: quantitative evaluation of the hierarchical medical system policy in China based on the PMC-Index model

BMC Public Health
Background China has made significant strides in healthcare, greatly enhancing health outcomes for its large population. However, disparities in medical resource distribution and utilization remain, making healthcare financially burdensome and ...
Liping Fu, Ruizhen Wang, Yu Dong
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Assessing the potential for scaling evidence-based interventions in African health systems: A deliberate dialogue

Health Research Policy and Systems
Background The WHO Regional Office for Africa reviewed evidence-based interventions designed to enhance health systems outputs: access, quality, demand and resilience.
Humphrey Cyprian Karamagi, Ali Ben Charif, Hillary Kipchumba Kipruto, Sokona Sy, Jacinta Nzinga, Araia Berhane, Tewelde Yohannes, Stephen Senkomago Musoke, Kyuree Kim, Kristina Tunheim, Solyana Ngusbrhan Kidane   +10 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The NBS data management technology program [PDF]

The National Bureau of Standards (NBS) Data Management Technology Program is discussed. The NBS Data Management Technology Program addresses major problems encountered during the following stages of an application's lifetime: requirements analysis and ...
Wood, H. M.
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Multidisciplinary Research Infrastructure: The Role of 21st Century Libraries Data Management Plan

, 2015
Kathryn Ruddock, John Brosz
openalex   +2 more sources

Grid Data Management in Action: Experience in Running and Supporting Data Management Services in the EU DataGrid Project

, 2003
In the first phase of the EU DataGrid (EDG) project, a Data Management System has been implemented and provided for deployment. The components of the current EDG Testbed are: a prototype of a Replica Manager Service built around the basic services ...
Andronico, Giuseppe, Donno, Flavia, Kunszt, Peter, Laure, Erwin, Millar, Paul, Muzaffar, Shahzad, Stockinger, Heinz   +6 more
core