Results 81 to 90 of about 3,038,884 (316)

Theory Building in Qualitative Research and Computer Programs for the Management of Textual Data [PDF]

, 1997
Udo Kelle
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Distortion Measurement Metric for Human Image Refinement and Evaluation Using Distorted Image Datasets

IEEE Access
This paper introduces novel evaluation metrics for quantifying distortion in human image retouching and presents a COCO-based retouched image dataset to validate their effectiveness.
Gwangyeol Yu, Kyungseo Yoon, Sangwoo Lee, Yeju Shin, Jonghyuk Park   +4 more
doaj   +1 more source

Big Data: Changes in Data Management

Ekonomski Vjesnik, 2016
Živimo u digitalnome okruženju u kojemu gotovo sve što radimo ostavlja digitalni trag. Podatci se prikupljaju iz raznih izvora - objava na društvenim mrežama, e-pošte, različitih senzora, slikovnih i video sadržaja, pretraga na tražilicama, online kupovina i mnogo drugih. Najveći razlog ovakvoga rasta podataka može se naći u tehnološkom napretku budući
Šebalj, Dario, Živković, Ana, Hodak, Kristina   +2 more
openaire   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dynamic analysis of a novel hyperchaotic system based on STM32 and application in image encryption

Scientific Reports
This paper presents a novel 4D hyperchaotic system derived from a modified 3D Lorenz chaotic system. A key aspect of this system is the presence of a single equilibrium point, and its stability is carefully analyzed. The dynamic properties, including the
XueFeng Cheng, Hongmei Zhu, Lian Liu, Kunpeng Mao, Juan Liu   +4 more
doaj   +1 more source

AI-driven Influencer and Market Analysis: A Social Network Approach to Measure E-Commerce Relationships

Journal of ICT
Social network analysis is a process of studying social structures and relationships using graph theory and data analysis techniques. It involves mapping and measuring connections and entities in a network.
Juhaida Abu Bakar, Chong Kar Min, Mohd Zulhisham Mohd Radzi, Fauziah Baharom, Yuhanis Yusof, Mohamed Ali Saip, Ruziana Muhamad Rasli, Muhammad Amirul Ariff Zulkifli, Nuratikah Jamaludin, Mustafa Ali Abuzaraida   +9 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source