Results 131 to 140 of about 3,154,859 (290)

Avionics test bed development plan [PDF]

open access: yes
The plan is for a facility for the early investigation and evaluation of new concepts for the control of large space structures, orbiter attached flex body experiments, and orbiter enhancements.
Harris, L. H.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A resource inventory for the Ruamahanga Catchment, Wairarapa, New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Applied Science at Massey University [PDF]

open access: yes, 2007
Currently, there is concern around various water management issues in the Ruamahanga Catchment, Wairarapa. This concern has prompted discussion among the stakeholders of the catchment about implementing an Integrated Catchment Management (ICM) Plan in ...
Chrystall, Leila Margaret
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Scientifically based biodiversity management in timber concessions: contribution to conservation and sustainable use of biodiversity [PDF]

open access: yes, 2016
During the past 25 years, forest laws in Central African countries have undergone major changes. Management plans were made mandatory: nearly 19 million hectares of timber concessions (38% of total granted concessions) were subject to a management plan ...
Bayol, Nicolas   +4 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Baltic Gender Data Management Plan : Version 1 [PDF]

open access: yes, 2017
Provides a summary of the Data Management Plan (DMP) addressing FAIR (findable, accessible, interoperable, re-usable) data, allocation of resources, data security and ethical ...
Matthes, Katja, Mehrtens, Hela
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Guidelines for the development of a Project Data Management Plan (PDMP) [PDF]

open access: yes
The purpose of this document is to assist NASA Project personnel in the preparation of their Project Data Management Plans (PDMP) in accordance with NASA Management Instruction (NMI) 8030.3A.
Green, James L., King, Joseph H.
core   +1 more source

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