Results 121 to 130 of about 459,037 (316)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Life cycle benzophenone 1 exposure induces anxiety- and depression-like behaviors in zebrafish via endoplasmic reticulum stress-mediated dopaminergic system dysfunction

Environmental Chemistry and Ecotoxicology
Environmental exposure to benzophenones (BPs) has emerged as a potential risk factor for the comorbidity of anxiety and depression. Among them, BP1 has attracted increasing attention due to its potential neurotoxic effects.
Zhipeng Qi, Peng Li, Xiang Gao, Qiuchen Wu, Keying Li, Zhuoyi Xie, Xilan Xia, Tianchen Wang, Xiangrong Zhou, Jianan Li, Xinying Zhao, Hui Yuan, Weiyi Song   +12 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Identification of Primary Metabolite Profiles Reveals Quality Characteristics of Citrus maxima ‘Shatian Yu’ from Different Origins

Current Issues in Molecular Biology
Citrus maxima ‘Shatian Yu’ displays varying nutritional profiles influenced by its production area. This study evaluated pomelo fruits from four primary and one developing ‘Shatian Yu’ production area. Notably, ‘Shatian Yu’ from the Guilin area exhibited
Yujiao Peng, Meixin Li, Fangfei Song, Shuilan Liu, Yuxiang Qin, Baoqing Hu, Xueyu Cui   +6 more
doaj   +1 more source

New ensemble methods for evolving data streams

, 2009
Advanced analysis of data streams is quickly becoming a key area of data mining research as the number of applications demanding such processing increases.
Richard Kirkby, Pfahringer, Bernhard, Geoff Holmes, Bernhard Pfahringer, Albert Bifet, Bifet, Albert, Kirkby, Richard Brendon, Holmes, Geoffrey, Gavaldà, Ricard, Ricard Gavaldà   +9 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Development and evaluation of multiepitope fusion proteins for serological diagnosis of animal brucellosis

Microbiology Spectrum
Brucellosis, a zoonotic disease caused by Brucella spp., leads to severe reproductive issues in livestock and economic losses. Current serological diagnostics using lipopolysaccharide (LPS) antigens often exhibit cross-reactivity, reducing diagnostic ...
Liping Guo, Qichuan Pei, Shiqi Zhao, Xinru Qi, Yixiao Chen, Peifei Yang, Yangguang Du, Mingjun Sun, Dehui Yin, Tiansong Zhan   +9 more
doaj   +1 more source

Phase Diagrams and Piezoelectric Properties of Wurtzite Al1−x−yScxGdyN Heterostructural Alloys

Advanced Science, EarlyView.
This study demonstrates ferroelectricity and piezoelectric properties improvement of quaternary wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films, guided by density functional theory calculations. Wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films have a high optical bandgap, enhanced piezoelectric ...
Julia L. Martin, Cheng‐Wei Lee, Nate S.P. Bernstein, Thi Nguyen, Ande Bryan, Eli Cooper, John S. Mangum, Sage R. Bauers, Andriy Zakutayev, Keisuke Yazawa, Prashun Gorai, Rebecca W. Smaha   +11 more
wiley   +1 more source

The contribution of data mining to information science

, 2004
The information explosion is a serious challenge for current information institutions. On the other hand, data mining, which is the search for valuable information in large volumes of data, is one of the solutions to face this challenge.
Liu, X, Xiaohui Liu, Chen, SY, Sherry Y. Chen   +3 more
core  

Apriori versions based on MapReduce for mining frequent patterns on big data

, 2018
Pattern mining is one of the most important tasks to extract meaningful and useful information from raw data. This task aims to extract item-sets that represent any type of homogeneity and regularity in data.
Francisco Padillo, Padillo, Francisco, Jose Maria Luna, Padillo, F., Pechenizkiy, M Mykola, Pechenizkiy, M., Luna, Jose Maria, Mykola Pechenizkiy, Ventura, S., Sebastian Ventura, Luna, J.M., Ventura, Sebastian, Pechenizkiy, M.; id_orcid   +12 more
core   +1 more source