Results 151 to 160 of about 23,785,135 (371)

Data Mining Concepts and Techniques

, 2010
S. Gnanapriya, R. Suganya, G. Devi, M. S. Kumar   +3 more
semanticscholar   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Deformation Prediction of 4D‐Printed Active Composite Structures Based on Data Mining

Advanced Science, EarlyView.
A curvature‐driven sequence point generation (CSPG) algorithm based on data mining is proposed to predict the deformation of double‐layer voxelized composite structures of arbitrary lengths. In addition, the CSPG algorithm is applied to predict the deformation of 2D and 3D structures assembled from beam elements, and its effectiveness is validated ...
Mengtao Wang, Yifan Xu, Zaiyang Liu, Hidemitsu Furukawa, Zhongkui Wang, Ren Xu, Lin Meng   +6 more
wiley   +1 more source

Location based Anomalies Detection on Geographical Map using Data Mining Techniques

, 2020
Dr. Prof. Amit. R. Gadekar
openalex   +1 more source

Metal–Organic Framework Featuring Monodispersed Silver Cation Sites for Highly Efficient and Selective Extraction of Aqueous Iodide Anions

Advanced Science, EarlyView.
A novel cationic metal–organic framework (MOF‐monoAg) featuring monodispersed silver (Ag+) sites is developed for the highly selective extraction of aqueous iodide ions (I−). MOF‐monoAg exhibits high accessibility, selectivity, and binding affinity toward I− ions, enabling superior iodine extraction from seawater and efficient iodide removal from ...
Xuewen Cao, Jiacheng Zhang, Jinjiao Pan, Yan Li, Yue Ma, Xinfeng Du, Lijuan Feng, Boyang Huang, Yihui Yuan, Liang Mao, Ning Wang, Abdullah M. Al‐Enizi, Ayman Nafady, Shengqian Ma   +13 more
wiley   +1 more source

Enhancing Binding by Electron Transfer at Heterointerfaces of Biochar‐Modified Hydrogel to Improve Utilization Efficiency of Wastewater Recovered Nutrients

Advanced Science, EarlyView.
Enhancing the utilization efficiency of nutrients recovered from wastewater is achieved through hydrogel modification by biochar. The strategy improves nutrient binding to hydrogels via electron transfer at heterointerfaces, thereby reducing nutrient release rate.
Hao Hu, Juncong Zou, Chenglin Zhang, Peng Li, Junnan Li, Yen Wah Tong, Jun Li, Yiliang He   +7 more
wiley   +1 more source

Automatic subspace clustering of high dimensional data for data mining applications

ACM SIGMOD Conference, 1998
R. Agrawal, J. Gehrke, D. Gunopulos, P. Raghavan   +3 more
semanticscholar   +1 more source