Results 201 to 210 of about 9,547,086 (304)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

FDBRP: A Data-Model Co-Optimization Framework Towards Higher-Accuracy Bearing RUL Prediction. [PDF]

Sensors (Basel)
Lin M, Ye Q, Na S, Qin D, Gao X, Liu Q.
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Pain when it "counts": hurdle analysis of clinical pain ratings improves data model performance. [PDF]

Pain Rep
Hogans BB, Siaton BC, Sorkin JD.
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Exploring common data model coverage of nursing flowsheet data: a pilot study using SNOMED CT and LOINC mapping. [PDF]

JAMIA Open
Austin R, Britt Lalich M, Stewart K, Zarbano J, Byrne M, Pinto MD, Umberfield EE.   +6 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Establishing standards: harmonising coding principles for a minimal cancer dataset in the OMOP Common Data Model. [PDF]

ESMO Real World Data Digit Oncol
Ajmal A, Bouissou O, Brash J, Cheeseman S, Banduge PG, Gomes AL, Revie L, Ross E, Theophanous S, Thonnard J, Van Maanen A, Vengadeswaran A, Wolf A, Fernandez XM.   +13 more
europepmc   +1 more source