Results 181 to 190 of about 12,296,497 (289)

Directly and Simultaneously Expressing Absolute and Relative Treatment Effects in Medical Data Models and Applications. [PDF]

Entropy (Basel), 2021
Teng H, Zhang Z.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Europe's Largest Research Infrastructure for Curated Medical Data Models with Semantic Annotations. [PDF]

Methods Inf Med
Riepenhausen S, Blumenstock M, Niklas C, Hegselmann S, Neuhaus P, Meidt A, Püttmann C, Storck M, Ganzinger M, Varghese J, Dugas M.   +10 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Entropy-metric estimation of the small data models with stochastic parameters. [PDF]

Heliyon
Kovtun V, Altameem T, Al-Maitah M, Kempa W.   +3 more
europepmc   +1 more source

Models, data models, and big data

Leticia Castillo Brache, Alisa Bokulich
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Attitudes Toward Common Data Models Among Chinese Biomedical Professionals: Cross-Sectional Survey.

JMIR Med Inform
Yu Y, Zheng Y, Zhang M, Xie J, You SC, Feng M, Zhan S, Sun F.   +7 more
europepmc   +1 more source

How to customize common data models for rare diseases: an OMOP-based implementation and lessons learned. [PDF]

Orphanet J Rare Dis
Ahmadi N, Zoch M, Guengoeze O, Facchinello C, Mondorf A, Stratmann K, Musleh K, Erasmus HP, Tchertov J, Gebler R, Schaaf J, Frischen LS, Nasirian A, Dai J, Henke E, Tremblay D, Srisuwananukorn A, Bornhäuser M, Röllig C, Eckardt JN, Middeke JM, Wolfien M, Sedlmayr M.   +22 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source