Results 141 to 150 of about 24,365,275 (295)

2D Gait Skeleton Data Normalization for Quantitative Assessment of Movement Disorders from Freehand Single Camera Video Recordings. [PDF]

Sensors (Basel), 2022
Tang W, van Ooijen PMA, Sival DA, Maurits NM.   +3 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Normalization discriminant independent component analysis

, 2013
In face recognition, feature extraction techniques attempts to search for appropriate representation of the data. However, when the feature dimension is larger than the samples size, it brings performance degradation.
Liew, Yee Ping, Lau, Siong Hoe, Pang, Ying Han, Bashier, Housam Khalifa, Ooi, Shih Yin   +4 more
core   +1 more source

An Improved Gaussian Mixture Model-Based Data Normalization Method for Removing Environmental Effects on Damage Detection of Structures

Buildings
In structural health monitoring, effectively eliminating the influence of variable environmental conditions on modal frequencies remains a critical challenge for accurate damage identification. Nonstationary and nonlinear variations in modal frequencies,
Xue-Yang Pei, Hai-Bin Huang, Peng Cao
doaj   +1 more source

Evaluation of Angelica decursiva reference genes under various stimuli for RT-qPCR data normalization. [PDF]

Sci Rep, 2021
He Y, Zhong Y, Bao Z, Wang W, Xu X, Gai Y, Wu J.   +6 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Python-Based Tool for Real-Time Reverse Osmosis Data Normalization in Desalination Applications

Engineering Proceedings
This work presents the development of a Python-based data normalization tool designed to facilitate RO performance monitoring The tool generates normalized metrics, including salt rejection, pressure difference, and permeate flow rate, providing a clear ...
Nitin Prasad, Abhilasha Maheshwari, Ganesh Kumar Pandian, Vijaysai Prasad   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

SMIXnorm: Fast and Accurate RNA-Seq Data Normalization for Formalin-Fixed Paraffin-Embedded Samples. [PDF]

Front Genet, 2021
Yin S, Zhan X, Yao B, Xiao G, Wang X, Xie Y.   +5 more
europepmc   +1 more source