Results 221 to 230 of about 26,006,190 (296)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Towards FAIR and federated data ecosystems for interdisciplinary research. [PDF]

PLoS Comput Biol
Beyvers S, Schlegel J, Brehm L, Hansen M, Goesmann A, Förster F.   +5 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Functional data analysis of lower-limb joint kinematics during badminton lunges under fatigue. [PDF]

Front Bioeng Biotechnol
Fang Y, Zhang X, Sun Y, Wu H, Pei H, Gao J, Liu J, Zhu Q, Gao Y.   +8 more
europepmc   +1 more source

Cephalometric analysis of the relationship between temporomandibular joint disc displacement and occlusal plane. [PDF]

BMC Oral Health
Liu Y, Zheng Y, Long Y, Ye C, Zhang Q, Zhou X, Xiong X, Wang J.   +7 more
europepmc   +1 more source

Atomically Resolved Acoustic Dynamics Coupled with Magnetic Order in a Van der Waals Antiferromagnet. [PDF]

Adv Mater
Zhou F, Hwangbo K, Ha SS, Zhang XW, Chun SH, Park J, Eom I, Jiang Q, Yang Z, Zajac M, Kim S, Choi S, Chu Z, Oh KH, Su Y, Zong A, Santos EJG, Cao T, Chu JH, Hruszkewycz SO, Gedik N, Xiao D, Kim H, Xu X, Wen H.   +24 more
europepmc   +1 more source

Efficacy of skeletally anchored modified leaf expander versus modified conventional Hyrax in maxillary molar distalization: a randomized clinical trial. [PDF]

BMC Oral Health
Elsaharty M, Abo-Elmahasen MMF, Eissa NM, Elbialy M.   +3 more
europepmc   +1 more source

Reliability of AI-driven cephalometric analysis on CBCT: comparison with manual 2D cephalometry. [PDF]

Prog Orthod
Kazimierczak N, Chwarścianek N, Sultani N, Janiszewska-Olszowska J, Jankowski T, Nowicka A, Serafin Z, Kazimierczak W.   +7 more
europepmc   +1 more source