Results 101 to 110 of about 68,191 (291)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Provable data possession scheme based on public verification and private verification

open access: yesTongxin xuebao, 2019
More and more users choose to transfer their applications and data into the cloud.Data security is a key issue for cloud storage systems.To ensure the integrity and validity of the data stored in the cloud,provable data possession (PDP) scheme is ...
Junfeng TIAN, Mengjia CHAI, Liuling QI
doaj   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Traditional health practitioners’ understanding of spirit possession in Gauteng province, South Africa

open access: yesHealth SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: Traditional health practitioners (THPs) understand spirit possession as a cultural or religious spirit occupying a person, while the mental healthcare providers understand it as a mental illness.
Ellen M. Thobakgale   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Analysis of FIFA 2023 Women’s World Cup match performance according to match outcome and phase of the tournament

open access: yesBiology of Sport
The aim of the study was to analyze the FIFA 2023 Women’s World Cup match performance according to match outcome and phase of the tournament. Match performance data were analyzed from a total of 64 games, which included a total of 32 national teams.
José M. Oliva-Lozano   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Cryptographic Accumulator-Based Scheme for Critical Data Integrity Verification in Cloud Storage

open access: yesIEEE Access, 2019
Public cloud storage is a fundamental cloud computing service. Currently, most owners of large data outsource their data to cloud storage services-even high-profile owners such as governments.
Walid I. Khedr   +2 more
doaj   +1 more source

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