Results 81 to 90 of about 584,673 (292)

Knowledge Collaboration: Working with Data and Web Specialists [PDF]

open access: yes, 2015
When resources are finite, people strive to manage resources jointly (if they do not rudely take possession of them). Organizing helps achieve—and even amplify—common purpose but often succumbs in time to organizational silos, teaming for the sake of ...
Serrat, Olivier
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Efficient Dynamic Replicated Data Possession Checking in Distributed Cloud Storage Systems

open access: yesInternational Journal of Distributed Sensor Networks, 2016
More and more organizations outsource their data to remote cloud servers (RCSs). Data owners rent the cloud service providers (CSPs) infrastructure to store their unlimited resources by paying fees metered in month or gigabyte.
Jinxia Wei   +3 more
doaj   +1 more source

Arresting Children: Examining Recent Trends in Preteen Crime [PDF]

open access: yes, 2008
Are juvenile offenders getting younger? The American public often hears policymakers and justice practitioners assert that young people are committing crimes at younger and younger ages. Is this true?
Howard N. Snyder, Jeffrey A. Butts
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Phase-of-Play Performance Profiles in Elite Women’s Futsal: Evidence from the FIFA Women’s Futsal World Cup 2025

open access: yesInspiree
The  purpose  of  the study. The purpose of this study was to analyze performance characteristics associated with in-possession, out-of-possession, and transition phases during the FIFA Women’s Futsal World Cup 2025.
Nufi Saidatus Tsaniyah   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Calculating effective gun policies

open access: yes, 2013
Following recent shootings in the USA, a debate has erupted, one side favoring stricter gun control, the other promoting protection through more weapons.
Komarova, Natalia L., Wodarz, Dominik
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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