Results 111 to 120 of about 1,987,659 (307)

Secure Session Key Management Scheme for Meter-Reading System Based on LoRa Technology

IEEE Access, 2018
Long range (LoRa) technology is a wireless communication technology, which may provide low-power, low-rate, and LoRa communication. It may widely be used into many applications, such as smart metering and factory monitoring.
Zhuoqun Xia, Hong Zhou, Ke Gu, Bo Yin, Youyou Zeng, Ming Xu   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning

Frontiers in Pharmacology
Computational drug repositioning, serving as an effective alternative to traditional drug discovery plays a key role in optimizing drug development.
Huimin Luo, Huimin Luo, Hui Yang, Hui Yang, Ge Zhang, Ge Zhang, Jianlin Wang, Jianlin Wang, Junwei Luo, Chaokun Yan, Chaokun Yan, Chaokun Yan   +11 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Multi-Level Intertemporal Attention-Guided Network for Change Detection in Remote Sensing Images

Remote Sensing
Change detection (CD) is detecting and evaluating surface changes by comparing Remote Sensing Images (RSIs) at different times, which is of great significance for environmental protection and urban planning.
Shuo Liu, Qinyu Zhang, Yuhang Zhang, Xiaochen Niu, Wuxia Zhang, Fei Xie   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

MPASL: multi-perspective learning knowledge graph attention network for synthetic lethality prediction in human cancer

Frontiers in Pharmacology
Synthetic lethality (SL) is widely used to discover the anti-cancer drug targets. However, the identification of SL interactions through wet experiments is costly and inefficient.
Ge Zhang, Ge Zhang, Yitong Chen, Yitong Chen, Chaokun Yan, Chaokun Yan, Jianlin Wang, Jianlin Wang, Wenjuan Liang, Wenjuan Liang, Junwei Luo, Huimin Luo, Huimin Luo   +12 more
doaj   +1 more source