Results 211 to 220 of about 334,461 (264)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Determinants of digital health literacy among health professionals: Evidence from public and private hospitals in Eastern Ethiopia. [PDF]

PLoS One
Asfaw E, Shiferaw T, Tolera M, Weldesenbet AB, Seid M.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Geometric Accuracy of 3D-Printed Composite Dental Restorations Compared with the Original STL Design. [PDF]

J Funct Biomater
Rossi T, Pascoletti G, Calì M, Baiamonte G, Monaco FCR, Zanetti EM, Audenino A, Serino G, Coppola B, Messina A, Scotti N.   +10 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Distributed denial of service detection and mitigation in software-defined networking-enabled software-defined wide area networks. [PDF]

PLoS One
Musa M, Ang TF, Chen YL, Bhatti UA, Ku CS, Luo Y, Chen J, Por LY.   +7 more
europepmc   +1 more source

Predictive performance of image processing techniques in the diagnosis of bone metastasis: A meta-analysis of a confusion matrix. [PDF]

Oncol Lett
Hu Y, Liao W, Er Y, Tao Q.
europepmc   +1 more source

Computer Vision-Based Techniques for Conveyor Belt Condition Monitoring: A Systematic Review. [PDF]

Sensors (Basel)
Rios-Colque P, Rios-Colque V, Rios-Colque L, Robles PA.   +3 more
europepmc   +1 more source

Vision-Language Models in Medical Imaging for Cancer Diagnosis: A Bibliometric Review. [PDF]

Bioengineering (Basel)
Wakili MA, Suleiman AB, Majikumna KU, Shehu HA, Kusetogullari H, Sharif MH.   +5 more
europepmc   +1 more source