Results 141 to 150 of about 12,427,514 (271)

Evaluating Data Quality by Proxy: Can We Evaluate All Dimensions of the European Medicines Agency Data Quality Framework for Registry-Based Post-Authorization Safety Studies? [PDF]

Pharmacoepidemiol Drug Saf
Dobay P, Sabidó M.
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Anomaly Detection for Automated Data Quality Monitoring in the CMS Detector. [PDF]

EPJ Res Infrastruct
Brinkerhoff A, Sutantawibul C, Suarez I, White R, Daumann C, Guiang J, Freer C, May S, Marsh B, Acosta D, Aubuchon A, Barberis E, Bundock A, Campagnari C, Collins E, Epps P, Erdmann J, Flaecher H, Huang J, Nguyen V, Nie R, Paramesvaran S, Rotter J, Salyer K, Sawant S, Sheokand T, Wood D, the CMS Muon Detector Collaboration.   +27 more
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Assessing Impact of Data Quality in Early Post-Operative Glioblastoma Segmentation. [PDF]

J Imaging
Helland RH, Bouget D, Jakola AS, Muller S, Solheim O, Reinertsen I.   +5 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Privacy-preserving data quality assessment for federated health data networks. [PDF]

BMC Med Inform Decis Mak
Tomášik R, Kussel T, Dudová Z, Kacová R, Hrstka R, Lablans M, Holub P.   +6 more
europepmc   +1 more source

Improving Data Quality: Consistency and Accuracy [PDF]

, 2007
Cong, Gao, Fan, Wenfei, Geerts, Floris, Jia, Xibei, Ma, Shuai   +4 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A governance framework for medical code standardization to enhance multi-institutional data quality. [PDF]

BMC Med Inform Decis Mak
Yamashita T, Shibata SI, Takada A, Hotta T, Izukura R, Kang D, Nakashima N.   +6 more
europepmc   +1 more source