Results 191 to 200 of about 4,105,012 (242)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Protocol for double-crosslinking ChIP-seq to improve data quality and enhance detection of challenging chromatin targets. [PDF]

STAR Protoc
Bao Y, Cacioppo R, Crisp A, Shlamovitz I, Sale JE, Tufegdzic Vidakovic A, Vervoort SJ, Zeller A.   +7 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Design and implementation of data quality controls in the EQ-DAPHNIE study: insights from the pilot phase and 15-country analysis. [PDF]

Qual Life Res
Al Sayah F, Short H, Ramos-Goñi JM, Viney R, Lubetkin EI, Janssen MF, Johnson JA, EQ-DAPHNIE Project Team.   +7 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Influence of skin pigmentation on the accuracy and data quality of photoplethysmographic heart rate measurement during exercise. [PDF]

Eur J Appl Physiol
Mulholland AM, MacDonald HV, Aguiar EJ, Wingo JE.   +3 more
europepmc   +1 more source

Establishing Best Practices for Clinical GWAS: Tackling Imputation and Data Quality Challenges. [PDF]

Int J Mol Sci
Casaburi G, McCullough R, D'Argenio V.
europepmc   +1 more source

Remote Consultations in England During COVID-19: Challenges in Data Quality, Linkage, and Research Validity. [PDF]

Online J Public Health Inform
Hidalgo-Padilla L, Dabbous M, Halvorsrud K, Beaney T, Gideon G, Gogarty E, Greenfield G, Hayhoe B, Kerr G, Raine R, Rehill N, Stewart R, Gaughran F, Pinto da Costa M.   +13 more
europepmc   +1 more source

Accounting for population structure and data quality in demographic inference with linkage disequilibrium methods. [PDF]

Nat Commun
Santiago E, Köpke C, Caballero A.
europepmc   +1 more source