Results 211 to 220 of about 11,695,622 (343)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero+8 more
wiley +1 more source
Publisher Correction: fNIRS reproducibility varies with data quality, analysis pipelines, and researcher experience. [PDF]
Yücel MA+108 more
europepmc +1 more source
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li+12 more
wiley +1 more source
Enhancing adverse drug reaction data quality in Canada: A high-precision pipeline for medication name standardization and enrichment. [PDF]
Chalabianloo N+5 more
europepmc +1 more source
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi+12 more
wiley +1 more source
Machine learning-based strategies for improving healthcare data quality: an evaluation of accuracy, completeness, and reusability. [PDF]
Jarmakovica A.
europepmc +1 more source
Nonparametric tests for trends in water-quality data using the statistical analysis system [PDF]
Charles G. Crawford+2 more
openalex +1 more source