Results 71 to 80 of about 29,969,840 (342)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Optimal timing of pharmacoinvasive strategy and its impact on clinical and economic outcomes in patients with ST-elevation myocardial infarction: a real-world perspective

Frontiers in Cardiovascular Medicine
BackgroundThe pharmacoinvasive (PhI) strategy is the standard-of-care for ST-elevation myocardial infarction (STEMI) patients when primary percutaneous coronary intervention (pPCI) is unfeasible.
Andrea Dias Stephanus, Alice Pacheco Santos, Ana Carolina Machado Rodrigues da Cunha, Ana Carolina Augusto Rocha, Amanda de Amorim Meireles, Mariana Guimarães Souza de Oliveira, Pietra Arissa Coelho Matsunaga, Alexandre Anderson de Sousa Munhoz Soares, Alexandre Anderson de Sousa Munhoz Soares, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Adriana de J. B. de Almeida Guimarães, Adriana de J. B. de Almeida Guimarães, Gustavo de Almeida Alexim, Alessandra M. Campos-Staffico, Luiz Sergio Fernandes de Carvalho, Luiz Sergio Fernandes de Carvalho, Luiz Sergio Fernandes de Carvalho   +19 more
doaj   +1 more source

The Challenges of Data Quality and Data Quality Assessment in the Big Data Era

Data Science Journal, 2015
High-quality data are the precondition for analyzing and using big data and for guaranteeing the value of the data. Currently, comprehensive analysis and research of quality standards and quality assessment methods for big data are lacking. First, this paper summarizes reviews of data quality research.
Yangyong Zhu, Li Cai
openaire   +5 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Data Quality and Curation

Data Science Journal, 2013
Data quality is an issue that touches on every aspect of the research data landscape and is therefore appropriate to examine in the context of planning for future research data infrastructures. As producers, researchers want to believe that they produce high quality data; as consumers, they want to obtain data of the highest quality.
openaire   +4 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

The costs of poor data quality

Journal of Industrial Engineering and Management, 2011
Purpose: The technological developments have implied that companies store increasingly more data. However, data quality maintenance work is often neglected, and poor quality business data constitute a significant cost factor for many companies. This paper argues that perfect data quality should not be the goal, but instead the data quality should be ...
Haug, Anders, Zachariassen, Frederik, Van Liempd, Dennis   +2 more
openaire   +8 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Cardiovascular and mortality benefits of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide 1 receptor agonists as third-step glucose-lowering medicine in patients with type 2 diabetes: a retrospective cohort analysis

BMJ Open Diabetes Research & Care
Introduction Studies have found that sodium-glucose cotransporter 2 inhibitors (SGLT2) and glucagon-like peptide 1 receptor agonists (GLP1) have cardiovascular benefits for patients with type 2 diabetes (DM2) and atherosclerotic cardiovascular disease ...
John L Adams, Thomas A McCormick, Jason Kramer, Elizabeth G Liles, Qiana Amos, John P Martin   +5 more
doaj   +1 more source